alpha-1-microglobulin

small plasma protein found in serum & urine of healthy individuals & in urine of patients with tubular proteinuria; alpha 1 microglobulin, guinea pig isolated from urine of guinea pigs with renal damage induced by Na chromate & is homologous to man; RefSeq NM_001633 (human); GenBank AB006444

Also Known As:

AMBP protein, human; Ambp protein, rat; ITI-LC protein, human; ITIL protein, human; alpha(1)-microglobulin; alpha(1)-microglycoprotein; alpha-1-microglobulin-bikunin precursor protein, human; alpha-1-microglobulin-bikunin precursor protein, rat; bikunin protein, human; bikunin protein, rat; inter-alpha-trypsin inhibitor, light chain protein, rat; protein HC; trypstatin protein, rat

Networked: 81 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Serum Globulins: 555
      - Alpha-Globulins: 99
        alpha-1-microglobulin: 81
  - Globulins: 3119
    - Serum Globulins: 555
      - Alpha-Globulins: 99
        alpha-1-microglobulin: 81

Experts

1.	Hansson, Stefan R: 6 articles (12/2022 - 01/2010)
2.	Åkerström, Bo: 4 articles (11/2020 - 04/2013)
3.	Erlandsson, Lena: 3 articles (12/2022 - 11/2020)
4.	Estrella, Michelle M: 3 articles (01/2021 - 01/2019)
5.	Parikh, Chirag R: 3 articles (01/2021 - 01/2019)
6.	Shlipak, Michael G: 3 articles (01/2021 - 01/2019)
7.	Zarbock, Alexander: 2 articles (05/2023 - 01/2023)
8.	von Groote, Thilo: 2 articles (05/2023 - 01/2023)
9.	Hansson, Eva: 2 articles (12/2022 - 11/2020)
10.	Shan, Xiaoyun: 2 articles (12/2021 - 05/2021)

Related Diseases

1.	Pre-Eclampsia (Preeclampsia) 01/01/2017 - "Recombinant alpha-1-microglobulin has the potential to become the first specific therapy for preeclampsia." 01/01/2017 - "Intravenous administration of recombinant alpha-1-microglobulin in animal models has been proved to eliminate or significantly reduce the manifestations of preeclampsia. " 02/23/2023 - "Mesenchymal stem cells, alpha-1-microglobulin, and antithrombin exhibit promising results in the treatment of preeclampsia in experimental models. " 04/01/2013 - "To study alpha-1-microglobulin (A1M), an endogenous radical scavenger and heme-binder, as a potential treatment for preeclampsia using the pregnant ewe preeclampsia model. " 11/26/2020 - "Alpha-1-microglobulin (A1M) is an antioxidant previously shown to be elevated in maternal blood during pregnancies complicated by preeclampsia and suggested to be important in the endogenous defense against oxidative stress. "
2.	Proteinuria 08/01/2005 - "Urinalysis revealed signs of tubulointerstitial damage, including leukocyturia and proteinuria with a high concentration of alpha(1)-microglobulin. " 06/01/2003 - "In the course of 220 infusions of HD-MTX, glomerular and tubular renal function was determined by measuring proteinuria and glomerular filtration rate (GFR), as well as renal excretion of alpha-1-microglobulin (AMG) and N-acetyl-beta-D-glucosaminidase (NAG). " 10/01/2000 - "Early kidney damage in 1021 people, occupationally or environmentally exposed to cadmium, was assessed from cadmium in urine to estimate dose, and protein HC (alpha(1)-microglobulin) in urine to assess tubular proteinuria. " 07/01/2000 - "Based on the excretion pattern of alpha(1)-microglobulin and albumin and its extent, significant tubular with significant glomerular proteinuria was found in seven diseased subjects. " 12/01/2006 - "Tubular proteinuria, glycosuria, high urinary N-acetyl-beta-D-glucosaminidase levels and alpha-1-microglobulin levels confirmed the tubular lesion. "
3.	Albuminuria 01/01/2013 - "Urinary NAG, urinary alpha-1-microglobulin, albuminuria, eGFR (CKD-EPI equation) were measured. " 02/01/2003 - "Hence, in addition to albuminuria (which measures glomerular dysfunction), urinary alpha(1)-microglobulin (which measures proximal tubular dysfunction) is useful for the early detection of nephropathy in diabetic subjects." 02/01/2003 - "Likewise, of patients with normal urinary alpha(1)-microglobulin, 27.6% had albuminuria. " 11/01/2001 - "The correlation between the degree of albuminuria and the protein HC excretion was significant at the time of kidney biopsy, but ceased to exist during the follow-up time. " 11/01/2001 - "The findings of the study suggest that the urinary protein HC concentration correlates to the degree of IgG-uria but not to the degree of albuminuria during the course of proteinuric glomerular disease. "
4.	Acute Kidney Injury (Acute Renal Failure) 01/01/2023 - "Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial)." 05/01/2023 - "Recombinant Alpha-1-Microglobulin (RMC-035) to Prevent Acute Kidney Injury in Cardiac Surgery Patients: Phase 1b Evaluation of Safety and Pharmacokinetics." 01/01/2021 - "Urine Alpha-1-Microglobulin Levels and Acute Kidney Injury, Mortality, and Cardiovascular Events following Cardiac Surgery." 03/01/2003 - "To evaluate the influence of dopamine and diltiazem on renal function and markers for acute renal failure, including urinary alpha-glutathion s-transferase (alpha-GST), alpha-1-microglobulin (alpha(1)-MG) and N-acetyl-ss-glucosaminidase (ss-NAG) after extracorporeal circulation. "
5.	Renal Insufficiency (Renal Failure) 05/01/2021 - "This study aimed to compare the ability of urinary alpha-1-microglobulin (a traditional tubular damage marker) with NGAL for evaluating renal insufficiency in patients with type-2 diabetes. " 05/01/2021 - "Significant association of urinary alpha-1-microglobulin compared to urinary neutrophil gelatinase-associated lipocalin with renal insufficiency in patients with type 2 diabetes." 03/01/1998 - "Patients developing renal insufficiency showed an increased excretion of alpha-1-microglobulin, and decreased excretions of Tamm-Horsfall-protein, angiotensinase A as well as a low renal blood flow. " 02/01/2006 - "In patients with idiopathic membranous nephropathy, an increased urinary excretion of high (IgG) and low [beta(2)-microglobulin (beta(2)M), alpha(1)-microglobulin (alpha(1)M)] molecular weight proteins predicts prognosis and precedes renal insufficiency. "

Related Drugs and Biologics

1.	Antithrombins
2.	Proteins (Proteins, Gene)
3.	Immunoglobulin G (IgG)
4.	Heme (Haem)
5.	Enzymes
6.	Uromodulin
7.	urinastatin (MR 20)
8.	Cystatin C
9.	Immunosorbents
10.	Albumins

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Extracorporeal Circulation
5.	Aftercare (After-Treatment)