|1.||Tata, Ada Maria: 5 articles (11/2015 - 04/2013)|
|2.||Di Bari, Maria: 4 articles (11/2015 - 04/2013)|
|3.||Conte, Claudia: 2 articles (11/2015 - 04/2013)|
|4.||Ricordy, Ruggero: 2 articles (11/2015 - 04/2013)|
|5.||Sciaccaluga, Miriam: 2 articles (11/2015 - 04/2013)|
|6.||Calogero, Antonella: 2 articles (01/2014 - 04/2013)|
|7.||Ponti, Donatella: 2 articles (01/2014 - 04/2013)|
|8.||Cristofaro, Ilaria: 1 article (11/2015)|
|9.||Conti, Luciano: 1 article (11/2015)|
|10.||Castigli, Emila: 1 article (11/2015)|
|1.||Oral Submucous Fibrosis
01/01/1987 - "Fibroblasts cultured in vitro from normal buccal tissue and from tissue from oral submucous fibrosis (OSF) associated with betel-nut chewing showed no significant difference in their rates of proliferation in culture, nor in the rate at which they hydrolysed the betel nut alkaloid arecoline to arecaidine. "
04/01/2001 - "Because alkaloids from areca nut, arecoline and arecaidine, have been implicated in the development of oral submucous fibrosis, we determined their diffusion kinetics through human buccal and vaginal mucosa. "
11/01/1995 - "This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro. "
02/01/2001 - "The cheek pouches were everted and painted with a solution of arecaidine three times weekly for up to an additional 4 weeks or until the tumor reached a size of 100 mm2. "
02/01/1996 - "After eight weeks of DMBA initiation and then four weeks of arecaidine promotion, 100% tumor incidence was found with arecaidine concentrations of 400 micrograms/ml and 500 micrograms/ml; average tumor numbers were 1.86 +/- 0.63 and 1.86 +/- 0.93 respectively (P < 0.05). "
02/01/1996 - "Without DMBA pretreatment, regardless of the high arecaidine concentrations (1000 micrograms/ml, 2000 micrograms/ml and 3000 micrograms/ml) applied, no visible tumor growth was observed; only hyperkeratosis and inflammation could be discerned histologically. "
02/01/1996 - "After four weeks of DMBA and a subsequent eight weeks of arecaidine painting, all hamsters developed visible tumors with arecaidine concentrations of 900 micrograms/ml and 1000 micrograms/ml; average tumor numbers were 1.86 +/- 0.82 and 2.14 +/- 1.09 respectively (P < 0.05). "
05/17/2010 - "Here, a reexamination of the metabolism of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), the suspect carcinogen areca alkaloids (arecoline, arecaidine, and arecoline 1-oxide), the hormone supplement melatonin, and the metabolism of the experimental cancer therapeutic agent aminoflavone is presented. "
|3.||Glioblastoma (Glioblastoma Multiforme)
11/01/2015 - "Considering the inability of conventional drugs to completely counteract the growth of glioblastoma cancer stem cells (GSCs), we have investigated the effect produced by arecaidine on GSC growth and survival. "
04/01/2013 - "Moreover, we have characterized the effects of the M2 agonist arecaidine on cell growth and survival both in two different glioblastoma cell lines (U251MG and U87MG) and in primary cultures obtained from different human biopsies. "
11/01/2015 - "Previously, we demonstrated that the muscarinic receptor agonist, arecaidine propargyl ester, via M2 receptors, inhibits cell proliferation in a time and dose-dependent manner and induces a severe apoptosis in human U251 and U87 glioblastoma cell lines. "
11/01/2015 - "Recently we have demonstrated that the activation of M2 muscarinic receptors, through arecaidine propargyl ester, arrests cell proliferation and induces apoptosis in primary and established glioblastoma cell lines. "
|4.||Schizophrenia (Dementia Praecox)
04/01/1978 - "Arecaidine and schizophrenia."
04/01/2012 - "We reviewed the clinical literature data since 1980 via a PubMed search for the terms: arecoline, arecaidine, guvacine, guvacoline, betel, Areca catechu, positive and negative symptoms, cognitive symptoms, psychosis and schizophrenia in combination. "
04/01/2013 - "Cell growth analysis has demonstrated that the M2 agonist arecaidine strongly decreased cell proliferation in both glioma cell lines and primary cultures. "
04/01/2013 - "Chemosensitivity assays have, moreover, shown arecaidine and temozolomide similar effects on glioma cell lines, although IC50 value for arecaidine was significantly lower than temozolomide. "
11/27/2012 - "Moreover the M2 antagonist gallamine counteracts the arecaidine effects confirming M2 receptor involvement in glioma cell growth inhibition. "
|3.||Interleukin-6 (Interleukin 6)
|4.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
|6.||Muscarinic M2 Receptor
|7.||Nerve Growth Factor (NGF)