carbamazepine epoxide

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9 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: metabolite of carbamazepine; RN given refers to unlabeled cpd

Also Known As:

10,11-epoxycarbamazepine; carbamazepine 10,11-epoxide; carbamazepine 10,11-oxide; carbamazepine epoxide, 1a-(13)C-labeled

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

3-Ring Heterocyclic Compounds

Dibenzazepines

Carbamazepine: 3942

carbamazepine epoxide: 9

Experts

1.	Winnicka, Renata I: 1 article (01/2002)
2.	Topaciński, Bogdan: 1 article (01/2002)
3.	Szymańska, Bozena: 1 article (01/2002)
4.	Szymczak, Wiesław M: 1 article (01/2002)

Related Diseases

1.	Epilepsy (Aura) 10/01/1997 - "Effect of lamotrigine on carbamazepine epoxide/carbamazepine serum concentration ratios in adult patients with epilepsy." 04/01/1996 - "Evaluation of carbamazepine and carbamazepine-epoxide protein binding in patients undergoing epilepsy surgery." 05/01/1990 - "Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three" 01/01/1996 - "Using a newly developed microdialysis probe which allows continuous monitoring of drugs in blood, we have studied the pharmacokinetics of various antiepileptic drugs (carbamazepine, and its primary metabolite carbamazepine-epoxide, phenytoin primidone and phenobarbitone) in 5 patients (2 male, 3 female, aged 40-50 years) with intractable epilepsy" Order ALL the reference details at left...
2.	Seizures (Seizure) 06/01/1994 - "Our experience shows that inconspicuous elevation of carbamazepine-epoxide levels during polytherapy may precipitate a distinct state of drug toxicity characterized by severe exacerbation of seizures" 04/01/1989 - "Carbamazepine and carbamazepine-epoxide serum concentrations in some resistant cases of complex partial seizures." 01/01/1987 - "This paper compares the results of plasma drug level estimations for 30 patients receiving clonazepam and 39 patients taking carbamazepine (assessing total and free carbamazepine concentrations together with carbamazepine epoxide levels) with the clinical features of seizure control" 06/01/1994 - "Analysis of the case histories and subsequent clinical follow-up for 1 1/2 to 3 years disclosed the following evidence that demonstrates the role of carbamazepine-epoxide in the development of the seizure exacerbation: (1) There were high serum carbamazepine-epoxide concentrations while serum carbamazepine concentrations were lower than or the same as baseline levels; (2) all patients were taking drugs that are known to increase serum carbamazepine-epoxide concentrations; (3) status epilepticus failed to respond to intravenous phenytoin loading; (4) seizure exacerbation in all patients was corrected by withholding carbamazepine dose; (5) seizure exacerbation recurred in 1 patient who resumed the same dose of carbamazepine; and (6) there were no prior status epilepticus or daily multiple seizures despite previous toxicities with other antiepileptic drugs in 3 patients" Order ALL the reference details at left...
3.	Poisoning 01/01/2002 - "Contrary to the suggestions found in the literature, carbamazepine 10,11-epoxide determination does not seem to enhance the possibility of anticipating the course of intoxication or the time of recovery." 01/01/2002 - "Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide." 01/01/1986 - "In five cases of carbamazepine (CBZ) intoxication, the time curves of the plasma concentration and of the renal excretion rate of carbamazepine and its metabolites carbamazepine 10,11-epoxide (CBZ-epoxide) and trans-10,11-dihydro-10,11-dihydroxy-CBZ (CBZ-diol) were measured" Order ALL the reference details at left...
4.	Status Epilepticus (Complex Partial Status Epilepticus) 06/01/1994 - "Analysis of the case histories and subsequent clinical follow-up for 1 1/2 to 3 years disclosed the following evidence that demonstrates the role of carbamazepine-epoxide in the development of the seizure exacerbation: (1) There were high serum carbamazepine-epoxide concentrations while serum carbamazepine concentrations were lower than or the same as baseline levels; (2) all patients were taking drugs that are known to increase serum carbamazepine-epoxide concentrations; (3) status epilepticus failed to respond to intravenous phenytoin loading; (4) seizure exacerbation in all patients was corrected by withholding carbamazepine dose; (5) seizure exacerbation recurred in 1 patient who resumed the same dose of carbamazepine; and (6) there were no prior status epilepticus or daily multiple seizures despite previous toxicities with other antiepileptic drugs in 3 patients" Order ALL the reference details at left...
5.	Drug Toxicity (Drug Safety) 06/01/1994 - "Our experience shows that inconspicuous elevation of carbamazepine-epoxide levels during polytherapy may precipitate a distinct state of drug toxicity characterized by severe exacerbation of seizures" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Carbamazepine (Tegretol)
2.	Phenytoin (Dilantin)
3.	Phenobarbital (Luminal)
4.	Anticonvulsants (Antiepileptic Drugs)
5.	Valproic Acid (Valproate, Semisodium)
6.	Primidone (Sertan)
7.	Clonazepam (Rivotril)
8.	Carrier Proteins (Binding Protein)
9.	lamotrigine (Lamictal)
10.	10,11- dihydro- 10,11- dihydroxy- 5H- dibenzazepine- 5- carboxamide

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