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1- palmitoyl- 2- linoleoyl- 3- acetyl- rac- glycerol

Also Known As:

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG); 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride; acetylated diacylglycerol PLAG

Networked: 14 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Glycerides: 109
  - 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol: 14

Experts

1.	Kim, Jae Wha: 12 articles (06/2022 - 06/2015)
2.	Sohn, Ki-Young: 12 articles (06/2022 - 06/2015)
3.	Yoon, Sun Young: 10 articles (06/2022 - 06/2015)
4.	Shin, Su-Hyun: 8 articles (06/2022 - 10/2016)
5.	Kim, Guen Tae: 4 articles (06/2022 - 02/2020)
6.	Jeong, Jinseon: 4 articles (01/2021 - 11/2019)
7.	Kim, Eun Young: 3 articles (06/2022 - 01/2022)
8.	Lee, Hyowon: 3 articles (06/2022 - 01/2022)
9.	Lee, Se Hee: 3 articles (06/2022 - 01/2022)
10.	Kim, Yong-Jae: 3 articles (01/2021 - 11/2019)

Related Diseases

1.	Neutropenia 02/05/2018 - "The chemical stability of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), a therapeutic agent for neutropenia, was investigated using a validated stability-indicating reversed phase high-performance liquid chromatographic (RP-HPLC) method. " 11/18/2019 - "Here, we investigated the protective effects of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) as a mitigator against 5-FU-induced hematologic toxicity, including neutropenia, monocytopenia, thrombocytopenia, and thrombocytosis, in Balb/c mice injected with 5-FU (100 mg/kg, i.p.). " 10/01/2016 - "In this study, we investigated whether 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride (PLAG), augments the therapeutic effect of pegfilgrastim on chemotherapy-induced neutropenia. "
2.	Neoplasms (Cancer) 01/01/2022 - "We examined the anti-tumor efficacy of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) in animal models, revealing the role of PLAG in inhibiting tumor progression by promoting the degradation of adenosine 2B receptors (A2BRs) in tumors. " 06/01/2022 - "In this study, tumor-implanted mouse models administered cisplatin showed rapid weight loss and reduced feeding rate by the second week of treatment, and 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) effectively alleviated cisplatin-induced cachexia. "
3.	Stomatitis 01/01/2020 - "This study was designed to investigate whether necroptosis is involved in the pathogenesis of chemoradiation-induced oral mucositis in a murine model and whether 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) ameliorates this disorder. " 01/01/2020 - "1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates chemoradiation-induced oral mucositis." 01/01/2020 - "1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol mitigated chemoradiation-induced oral mucositis by modulating necroptosis."
4.	Thrombocytosis (Thrombocythemia) 11/18/2019 - "Here, we investigated the protective effects of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) as a mitigator against 5-FU-induced hematologic toxicity, including neutropenia, monocytopenia, thrombocytopenia, and thrombocytosis, in Balb/c mice injected with 5-FU (100 mg/kg, i.p.). "
5.	Thrombocytopenia (Thrombopenia) 11/18/2019 - "Here, we investigated the protective effects of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) as a mitigator against 5-FU-induced hematologic toxicity, including neutropenia, monocytopenia, thrombocytopenia, and thrombocytosis, in Balb/c mice injected with 5-FU (100 mg/kg, i.p.). "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Adenosine (Adenocard)
3.	Therapeutic Uses
4.	Cisplatin (Platino)
5.	pegfilgrastim (Neulasta)
6.	Diglycerides
7.	Chemokines
8.	Uric Acid (Urate)
9.	Lipids
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)