CB002

09/17/2017 - "In this study, a compound referred to as CB002 with one closely related compound from the Chembridge library were evaluated for tumor cytotoxicity without affecting normal cells by restoration of the p53 pathway. "
01/01/2018 - "In summary, CB002, a p53 pathway-restoring compound that targets mutant p53 for degradation and induces tumor cell death through NOXA, may be further developed as a cancer therapeutic."
01/01/2018 - "Moreover, CB002 decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells. "
09/17/2017 - "However, it is important to note that we have not established a role for p73 in the anti-tumor effect of CB002 or R1. "
09/17/2017 - "We further show that CB002 activates p53 pathway signaling in part via p73 in p53 mutant cancer cell lines. "

01/01/2018 - "We identified CB002, as a candidate that restores p53 function in mutant p53-expressing colorectal cancer cells and without toxicity to normal human fibroblasts. "
09/17/2017 - "Small-molecule CB002 restores p53 pathway signaling and represses colorectal cancer cell growth."