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YNT-185

an orexin type-2 receptor (OX2R) selective agonist

Also Known As:

2-(dimethylamino)-N-(2-(3-((5-(3-(dimethylcarbamoyl)phenyl)-2-methoxyphenyl)sulfonylamino)anilino)ethyl)benzamide

Networked: 6 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 140

Experts

1.	Yanagisawa, Masashi: 3 articles (09/2023 - 01/2017)
2.	Ishikawa, Yukiko: 2 articles (09/2023 - 01/2017)
3.	Saitoh, Tsuyoshi: 2 articles (09/2023 - 01/2017)
4.	Irukayama-Tomobe, Yoko: 2 articles (11/2018 - 01/2017)
5.	Elhosainy, Asmaa: 1 article (09/2023)
6.	Funato, Hiromasa: 1 article (09/2023)
7.	Hotta-Hirashima, Noriko: 1 article (09/2023)
8.	Kaushik, Mahesh K: 1 article (09/2023)
9.	Kim, Staci J: 1 article (09/2023)
10.	Miyoshi, Chika: 1 article (09/2023)

Related Diseases

1.	Absence Epilepsy (Childhood Absence Epilepsy) 01/01/2023 - "This study investigated the efficacy of YNT-185 for the first time on absence epilepsy in GAERS and revealed a suppressive effect of OX2R agonist on SWDs as evidenced by the significantly reduced expression of OX2R in the cortex and thalamus. "
2.	Disorders of Excessive Somnolence (Hypersomnia) 09/05/2023 - "Intraperitoneal YNT-185 promoted wakefulness for 3 h after injection in Sleepy mice, indicating the potential of using orexin agonists to treat not only orexin deficiency but hypersomnolence of various etiologies." 11/01/2018 - "Additionally, YNT-185 promoted wakefulness in wild-type mice, suggesting that orexin receptor agonists may be useful for the treatment of excessive daytime sleepiness due to other conditions, such as sleepiness accompanying depression and sleepiness due to side effects of medicines or jet lag/shift work."
3.	Sleepiness 09/05/2023 - "We then investigated the effect of orexin-A and the orexin receptor 2-selective agonist YNT-185 on the sleepiness symptoms of the Sleepy mouse. " 11/01/2018 - "Additionally, YNT-185 promoted wakefulness in wild-type mice, suggesting that orexin receptor agonists may be useful for the treatment of excessive daytime sleepiness due to other conditions, such as sleepiness accompanying depression and sleepiness due to side effects of medicines or jet lag/shift work."
4.	Jet Lag Syndrome 11/01/2018 - "Additionally, YNT-185 promoted wakefulness in wild-type mice, suggesting that orexin receptor agonists may be useful for the treatment of excessive daytime sleepiness due to other conditions, such as sleepiness accompanying depression and sleepiness due to side effects of medicines or jet lag/shift work."
5.	Narcolepsy 11/01/2018 - "We show that peripheral administration of YNT-185 significantly ameliorated the narcolepsy symptoms in a mouse model for narcolepsy. " 10/01/2020 - "YNT-185 is the first known small molecule acting as orexin 2 receptor (OX2R) agonist with implication to narcolepsy treatment, served as a template scaffold in generating a small set of seven compounds with predictive affinity to OX2R. "

Related Drugs and Biologics

1.	Orexin Receptors
2.	Orexins
3.	Cannabinoid Receptors (Cannabinoid Receptor)
4.	Rimonabant