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2- (3- (4- chlorobenzoyl)thioureido)- 4- ethyl- 5- methylthiophene- 3- carboxamide

a PI4KIIalpha inhibitor; structure in first source

Also Known As:

PI-273

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - 2-(3-(4-chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide: 1
- Sulfur Compounds: 278
  - Thiourea: 362
    - 2-(3-(4-chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide: 1
  - Thiophenes: 257
    - 2-(3-(4-chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 2-(3-(4-chlorobenzoyl)thioureido)-4-ethyl-5-methylthiophene-3-carboxamide: 1

Experts

1.	Chen, Chang: 1 article (11/2017)
2.	Ding, Hong: 1 article (11/2017)
3.	Gao, Zhen: 1 article (11/2017)
4.	Jiang, Hualiang: 1 article (11/2017)
5.	Li, Jiangmei: 1 article (11/2017)
6.	Liu, Jia: 1 article (11/2017)
7.	Lu, Junyan: 1 article (11/2017)
8.	Luo, Cheng: 1 article (11/2017)
9.	Qiao, Xinhua: 1 article (11/2017)
10.	Zhang, Lunfeng: 1 article (11/2017)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2017 - "PI-273 is the first substrate-competitive, subtype-specific inhibitor of PI4KIIα, the use of which will facilitate evaluations of PI4KIIα as a cancer therapeutic target. "
2.	Breast Neoplasms (Breast Cancer) 11/15/2017 - "Importantly, PI-273 significantly inhibited MCF-7 cell-induced breast tumor growth without toxicity. " 11/15/2017 - "PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells."