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CGK012

has antineoplastic activity; structure in first source

Also Known As:

cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano(3,2-g)chromen-7-yl-ester

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - CGK012: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        CGK012: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        CGK012: 1

Experts

1.	Choi, Pyung Jun: 1 article (01/2017)
2.	Her, Jin-Hyuk: 1 article (01/2017)
3.	O, Yuseok: 1 article (01/2017)
4.	Oh, Sangtaek: 1 article (01/2017)
5.	Song, Gyu Yong: 1 article (01/2017)
6.	Yun, Eunju: 1 article (01/2017)

Related Diseases

1.

Multiple Myeloma

01/01/2017 - "These findings suggest that CGK012 could exert antiproliferative activity against multiple myeloma cells by attenuating the Wnt/β-catenin pathway; thus, it may have potential as a therapeutic agent for multiple myeloma treatment."
01/01/2017 - "Anti-proliferative activity of CGK012 against multiple myeloma cells via Wnt/β-catenin signaling attenuation."
01/01/2017 - "Furthermore, CGK012 consistently decreased the amount of β-catenin and repressed the expression of cyclin D1, c-myc, and axin-2 (downstream target genes of β-catenin) in RPMI-8226 multiple myeloma cells. "

Related Drugs and Biologics

1.	Catenins
2.	Cyclin D1