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PAT-048

selective autotaxin inhibitor, Phosphodiesterase Inhibitors

Also Known As:

3-(6-chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl-1H-indol-3-yl-sulfanyl))-2-fluoro-benzoic sodium salt

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        PAT-048: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - PAT-048: 2

Experts

1.	Bain, Gretchen: 2 articles (12/2016 - 01/2016)
2.	Black, Katharine E: 2 articles (12/2016 - 01/2016)
3.	Castelino, Flavia V: 2 articles (12/2016 - 01/2016)
4.	Goulet, Lance: 2 articles (12/2016 - 01/2016)
5.	Probst, Clemens K: 2 articles (12/2016 - 01/2016)
6.	Tager, Andrew M: 2 articles (12/2016 - 01/2016)
7.	George, Leaya: 1 article (12/2016)
8.	Lafyatis, Robert: 1 article (12/2016)
9.	Pace, Veronica A: 1 article (12/2016)
10.	Ahluwalia, Neil: 1 article (01/2016)

Related Diseases

1.

Fibrosis (Cirrhosis)

12/01/2016 - "PAT-048 markedly attenuated bleomycin-induced dermal fibrosis when treatment was initiated before or after the development of fibrosis. "
01/01/2016 - "Further, administration of the potent ATX inhibitor PAT-048 to bleomycin-challenged mice markedly decreased ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis. "
12/01/2016 - "We evaluated the effect of a novel ATX inhibitor, PAT-048, on fibrosis and IL-6 expression in the mouse model of bleomycin-induced dermal fibrosis. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Interleukin-6 (Interleukin 6)