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3- (dipropylamino)- 5- hydroxybenzofuro(2,3- f)quinazolin- 1(2H)- one

has antineoplastic activity; structure in first source

Also Known As:

DPA-HBFQ-1

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - Quinazolinones: 124
        3-(dipropylamino)-5-hydroxybenzofuro(2,3-f)quinazolin-1(2H)-one: 1
    - Benzofurans: 26
      - 3-(dipropylamino)-5-hydroxybenzofuro(2,3-f)quinazolin-1(2H)-one: 1

Experts

1.	Andò, Sebastiano: 1 article (01/2016)
2.	Caruso, Anna: 1 article (01/2016)
3.	Catalano, Stefania: 1 article (01/2016)
4.	Dallemagne, Patrick: 1 article (01/2016)
5.	El-Kashef, Hussein: 1 article (01/2016)
6.	Giordano, Francesca: 1 article (01/2016)
7.	Iacopetta, Domenico: 1 article (01/2016)
8.	Lancelot, Jean Charles: 1 article (01/2016)
9.	Lesnard, Aurelien: 1 article (01/2016)
10.	Pellegrino, Michele: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "Our results indicate DPA-HBFQ-1 as a good candidate to be useful as cancer therapeutic agent, particularly for breast cancer. " 01/01/2016 - "The observed effects have been ascribed to an enhanced p21(Cip1/WAF1) expression in a p53-dependent manner of tumor suppressor and to a selective inhibition of human topoisomerase II. In addition, DPA-HBFQ-1 exerted growth inhibitory effects also in other cancer cell lines, even though with a lower cytotoxic activity. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "The cytotoxic activities of all the synthesized compounds, tested in different human breast cancer cell lines, revealed that DPA-HBFQ-1 was the most active compound. " 01/01/2016 - "Our results indicate DPA-HBFQ-1 as a good candidate to be useful as cancer therapeutic agent, particularly for breast cancer. "

Related Drugs and Biologics

1.	Type II DNA Topoisomerases (Topoisomerase II)