DSR-98776

an mGlu5 receptor negative allosteric modulator with both antidepressant and antimanic activities; structure in first source

Also Known As:

(3-fluorophenyl)(2-(5-fluoropyridin-2-yl))-6,7-dihydro(1,3)oxazolo(4,5-c)pyridin-5(4H)-yl)methanone

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Mania (Manias) 06/15/2015 - "The in vivo therapeutic benefits of DSR-98776 were evaluated in common rodent models of depression and mania. " 06/15/2015 - "This study pharmacologically characterized a structurally novel metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulator, DSR-98776, and evaluated its effect on rodent models of depression and mania. "
2.	Mood Disorders (Mood Disorder) 06/15/2015 - "These results indicate that DSR-98776 acts as an orally potent antidepressant and antimanic in rodent models and can be a promising therapeutic option for the treatment of a broad range of mood disorders with depressive and manic states."

1.	Glutamic Acid (Glutamate)
2.	Antidepressive Agents (Antidepressants)