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RSM-932A

a choline kinase inhibitor with antimalarial activity; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - RSM-932A: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolinium Compounds: 1
        RSM-932A: 3

Experts

1.	Lacal, Juan Carlos: 3 articles (01/2020 - 12/2013)
2.	Zimmerman, Tahl: 2 articles (01/2020 - 12/2013)
3.	Chasten, Valerie: 1 article (01/2020)
4.	Ibrahim, Salam A: 1 article (01/2020)
5.	Campos, Joaquín M: 1 article (01/2015)
6.	Bautista, José Manuel: 1 article (12/2013)
7.	Cebrián, Arancha: 1 article (12/2013)
8.	Diez, Amalia: 1 article (12/2013)
9.	Gómez Del Pulgar, Teresa: 1 article (12/2013)
10.	Moneriz, Carlos: 1 article (12/2013)

Related Diseases

1.	Parasitemia 12/01/2013 - "RSM-932A and MN58b significantly reduced parasitemia and induced the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion, suggesting a delay of the parasite maturation stage. "
2.	Neoplasms (Cancer) 01/01/2015 - "Among these inhibitors, RSM-932A has been chosen for further clinical development due to its potent antiproliferative activity in vitro against a large variety of tumor-derived cell lines, a potent in vivo anticancer activity, and lack of toxicity at the effective doses. " 01/01/2015 - "Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells."
3.	Autolysis 01/01/2020 - "Cells treated with MN58b but not RSM-932A were more sensitive to a phosphate induced autolysis with respect to the untreated cells. "

Related Drugs and Biologics

1.	1,4- (4- 4'- Bis- ((4- (dimethylamine)pyridinium- 1- yl) methyl)diphenyl)butane dibromide
2.	Phosphates (Orthophosphate)
3.	Enzymes
4.	Choline Kinase