Abstract |
The objectives of the studies presented here were to assess the safety and efficacy of the adjunctive administration of sub-antimicrobial-dose doxycycline (SDD) for the treatment of adult periodontitis and to confirm the optimal dosing regimen. The studies summarized included four double-blind, placebo-controlled, randomized clinical trials, conducted over a period of 9 to 12 months. Analysis of efficacy data demonstrated that adjunctive SDD treatment resulted in: (1) increases in clinical attachment levels; (2) decreases in probing pocket depths; and (3) reductions in bleeding on probing in patients with adult periodontitis. There were no significant adverse events or unwanted long-term antimicrobial effects associated with orally administered SDD. The results of these clinical trials indicate that the adjunctive use of SDD 20 mg BID is an effective and well-tolerated regimen which can significantly improve several indices of periodontal health.
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Authors | S Ciancio, R Ashley |
Journal | Advances in dental research
(Adv Dent Res)
Vol. 12
Issue 2
Pg. 27-31
(Nov 1998)
ISSN: 0895-9374 [Print] United States |
PMID | 9972118
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Doxycycline
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Topics |
- Adult
- Alveolar Bone Loss
(drug therapy, pathology)
- Analysis of Variance
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Disease Progression
- Double-Blind Method
- Doxycycline
(administration & dosage, therapeutic use)
- Humans
- Least-Squares Analysis
- Periodontal Attachment Loss
(drug therapy, pathology)
- Periodontal Index
- Periodontitis
(drug therapy, therapy)
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