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Safety and efficacy of sub-antimicrobial-dose doxycycline therapy in patients with adult periodontitis.

Abstract
The objectives of the studies presented here were to assess the safety and efficacy of the adjunctive administration of sub-antimicrobial-dose doxycycline (SDD) for the treatment of adult periodontitis and to confirm the optimal dosing regimen. The studies summarized included four double-blind, placebo-controlled, randomized clinical trials, conducted over a period of 9 to 12 months. Analysis of efficacy data demonstrated that adjunctive SDD treatment resulted in: (1) increases in clinical attachment levels; (2) decreases in probing pocket depths; and (3) reductions in bleeding on probing in patients with adult periodontitis. There were no significant adverse events or unwanted long-term antimicrobial effects associated with orally administered SDD. The results of these clinical trials indicate that the adjunctive use of SDD 20 mg BID is an effective and well-tolerated regimen which can significantly improve several indices of periodontal health.
AuthorsS Ciancio, R Ashley
JournalAdvances in dental research (Adv Dent Res) Vol. 12 Issue 2 Pg. 27-31 (Nov 1998) ISSN: 0895-9374 [Print] United States
PMID9972118 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Doxycycline
Topics
  • Adult
  • Alveolar Bone Loss (drug therapy, pathology)
  • Analysis of Variance
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Disease Progression
  • Double-Blind Method
  • Doxycycline (administration & dosage, therapeutic use)
  • Humans
  • Least-Squares Analysis
  • Periodontal Attachment Loss (drug therapy, pathology)
  • Periodontal Index
  • Periodontitis (drug therapy, therapy)

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