Trovafloxacin provides broad in vitro and in vivo coverage of the aerobic and anaerobic pathogens found frequently in surgical
infections. In vitro susceptibility testing indicated that
trovafloxacin inhibited gram-positive staphylococci and enterococci, numerous gram-negative organisms, including Escherichia coli, and anaerobic pathogens, such as Bacteroides fragilis.
Trovafloxacin protected mice from lethal
infections induced by gram-negative or gram-positive organisms, even when these organisms were inoculated in combination with B. fragilis.
Trovafloxacin protected rats in models of intra-abdominal
sepsis induced by inoculation with E. coli and B. fragilis or with multiple aerobic and anaerobic pathogens. In these experimental models,
trovafloxacin protected rats from lethal
infection, reduced
intra-abdominal abscess formation, and inhibited bacterial growth.
Drug concentrations were greater in
intra-abdominal abscesses than in serum, reflecting the good tissue penetration of
trovafloxacin. These results indicate that
trovafloxacin may be effective in prophylaxis and treatment of
mixed infections in surgical patients.