Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone.

Abstract

The changes in nerve function tests in 297 new leprosy patients over an average period of 30 months were measured. The impact of type 1 reactions (T1R) on sensory and voluntary muscle function was measured by standard tests. Sensory function was improved in patients with single episodes of cutaneous T1R, but not improved in patients with neural T1R or with multiple episodes of either kind of T1R. Patients over 40 years of age improved less than younger patients, and patients admitted for treatment of T1R improved more than those treated as outpatients. These data point to a need to find better regimens for the treatment of nerve damage in T1R.

• Authors: P W Roche, W J Theuvenet, J W Le Master, C R Butlin
• Journal: International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association (Int J Lepr Other Mycobact Dis) Vol. 66 Issue 3 Pg. 340-7 (Sep 1998) ISSN: 0148-916X [Print] United States
• PMID: 9934360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Prednisolone

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Anti-Inflammatory Agents (therapeutic use)
• Child
• Cohort Studies
• Disability Evaluation
• Female
• Humans
• Leprosy, Borderline (drug therapy, physiopathology)
• Male
• Middle Aged
• Motor Neurons (physiology)
• Neurons, Afferent (physiology)
• Prednisolone (therapeutic use)
• Retrospective Studies