Abstract | BACKGROUND: METHODS: In 598 women treated for cervical intraepithelial neoplasia grade 3 the state of the resection margins was recorded and related to the findings on follow-up, up to 15 years post-operatively. Lesion-free survival times were analyzed by the Kaplan-Meier method. The presence/absence of human papillomavirus infection and/or p53 expression in the primary lesion was investigated in every fifth case by in situ hybridization and immunohistochemistry respectively. RESULTS: Lesion-free survival was significantly more common after complete than incomplete excision of cervical intraepithelial neoplasia. In the latter, lesions tended to appear shortly after surgery, indicating the presence of residual disease. The few lesions appearing later were evenly divided between those with and those without complete excision. The results of the human papillomavirus and p53 investigations added no further information. CONCLUSIONS:
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Authors | B Bertelsen, T Tande, R Sandvei, F Hartveit |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 78
Issue 1
Pg. 54-9
(Jan 1999)
ISSN: 0001-6349 [Print] United States |
PMID | 9926893
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Conization
(methods)
- Female
- Humans
- Lasers
- Neoplasm Recurrence, Local
- Neoplasm Staging
- Papillomaviridae
- Papillomavirus Infections
(pathology, surgery, virology)
- Uterine Cervical Dysplasia
(pathology, surgery)
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