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Role of nitric oxide in cardiovascular responses to endotoxemia in neonatal lambs.

Abstract
To determine whether systemic cardiovascular responses to gram-negative endotoxemia are mediated by nitric oxide, we evaluated time-dependent changes in contractility and hemodynamics in a neonatal sheep model subjected to nitric oxide synthesis inhibition with L-Name (Nomega-nitro-L-arginine methyl ester). Four groups were studied: control (C), endotoxin (E), endotoxin L-Name where the nitric oxide synthase inhibitor was given prior to endotoxin (ELN), and a control L-Name group pretreated with L-Name (CLN). The contractility, measured as end-systolic elastance (Ees), increased transiently in the E group and then returned to baseline. In contrast, Ees declined over time in the ELN group. In terms of peripheral hemodynamics, both the E and ELN groups demonstrated significant progressive decreases in blood pressure and vascular resistance. The results of this study suggest that nitric oxide contributes to the newborn contractile response of the heart to endotoxin, but does not appear to mediate the systemic vascular relaxation response.
AuthorsJ M Milstein, E Milano, B W Goetzman, S H Bennett
JournalBiology of the neonate (Biol Neonate) Vol. 75 Issue 3 Pg. 187-98 (Mar 1999) ISSN: 0006-3126 [Print] Switzerland
PMID9925906 (Publication Type: Journal Article)
Chemical References
  • Bacterial Toxins
  • Enterotoxins
  • Enzyme Inhibitors
  • Escherichia coli Proteins
  • Nitric Oxide
  • heat-labile enterotoxin, E coli
  • Nitric Oxide Synthase
  • NG-Nitroarginine Methyl Ester
Topics
  • Animals
  • Animals, Newborn (physiology)
  • Bacterial Toxins (pharmacology)
  • Blood Gas Analysis
  • Blood Pressure
  • Cardiovascular Physiological Phenomena (drug effects)
  • Endotoxemia (physiopathology)
  • Enterotoxins (pharmacology)
  • Enzyme Inhibitors (pharmacology)
  • Escherichia coli
  • Escherichia coli Proteins
  • Heart Function Tests
  • NG-Nitroarginine Methyl Ester (pharmacology)
  • Nitric Oxide (physiology)
  • Nitric Oxide Synthase (antagonists & inhibitors)
  • Oximetry
  • Regression Analysis
  • Sheep
  • Vascular Resistance

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