Abstract | BACKGROUND: AIM: PATIENTS AND METHODS: Eighteen women with clinical and biochemical evidence of hyperandrogenism, normal oral glucose tolerance test and polycystic ovaries on ultrasonography, were studied. Insulin sensitivity was assessed using the insulin tolerance test. LH secretion was studied integrating LH values of blood samples taken every 10 minutes for 6 h. Testosterone, testosterone index, SHBG and IGFBP-1 were measured in three selected samples and ovarian volume was assessed by ultrasound. RESULTS:
Insulin sensitivity ranged from 0.06 to 0.75 and the area under the curve for LH, from 532 to 8.517 IU/L/6 h. No correlation was found between these two parameters and between each parameter and ovarian volume or androgen concentration. Positive correlations were observed between insulin sensitivity and SHBG concentrations (r = 0.612 p < 0.01) and IGFBP-1 concentrations (r = 0.588 p < 0.001). When compared to patients body mass index of less than 30 kg/m2, patients with body mass index over 30 kg/m2 had significantly lower insulin sensitivity and higher LH levels. In the latter a positive correlation between insulin sensitivity and the area under the curve for LH was observed (r = 0.683 p < 0.02). CONCLUSIONS:
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Authors | T Sir-Petermann, F Alba, T Castillo, A Muñoz, A Cortínez, M Maliqueo, M Calvillán |
Journal | Revista medica de Chile
(Rev Med Chil)
Vol. 126
Issue 9
Pg. 1049-57
(Sep 1998)
ISSN: 0034-9887 [Print] Chile |
Vernacular Title | Síndrome de ovario poliquístico: relación entre sensibilidad tisular a la insulina, secreción de LH y cambios morfofuncionales ováricos. |
PMID | 9922507
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Female
- Humans
- Insulin Resistance
- Luteinizing Hormone
(metabolism)
- Ovary
(pathology, physiopathology)
- Polycystic Ovary Syndrome
(complications, metabolism)
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