Long-term results of isotretinoin in the treatment of 68 patients with hidradenitis suppurativa.

Abstract

BACKGROUND:

Oral isotretinoin has been used to treat mild to severe hidradenitis suppurativa (HS).

OBJECTIVE:

We reviewed the results of low-dose isotretinoin for 4 to 6 months in the treatment of 68 patients with HS.

METHODS:

This is a retrospective study. Data are presented in terms of response rate, long-term follow-up, and the relation between response rate and severity.

RESULTS:

In 16 patients (23.5%), the condition completely cleared during initial therapy and 11 patients (16.2%) maintained their improvement during the follow-up period. Treatment was more successful in the milder forms of HS.

CONCLUSION:

Monotherapy with isotretinoin for patients with HS usually has a limited therapeutic effect.

• Authors: J Boer, M J van Gemert
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 40 Issue 1 Pg. 73-6 (Jan 1999) ISSN: 0190-9622 [Print] United States
• PMID: 9922015 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Keratolytic Agents
• Isotretinoin

Topics

• Adult
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Hidradenitis Suppurativa (drug therapy)
• Humans
• Isotretinoin (administration & dosage, therapeutic use)
• Keratolytic Agents (administration & dosage, therapeutic use)
• Male
• Retrospective Studies
• Time Factors
• Treatment Outcome