31P NMR spectroscopy can predict the optimum interval between fractionated irradiation doses.
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| Abstract |
This study was performed to clarify whether changes in the metabolites observed by phosphorous-31 magnetic resonance spectroscopy (31P-MRS) could indicate an optimum interval between two doses of radiation in a murine tumor model. Murine mammary carcinoma cells, FM3A, were irradiated 7 days after transplantation with a single 5 Gy dose without anesthesia. 31P spectra were measured with a spectrometer up to 30 days. The beta-ATP/Pi and PCr/Pi values were calculated from the peak area of each spectrum. In a fractionation experiment, two fractions of irradiation at a 5 Gy per fraction were given at 0, 1, 2, 3 and 6 day intervals. Tumor growth delay was also scored to determine the fractionated radiation effect. In the control group, beta-ATP/Pi and PCr/Pi decreased with tumor growth. In the single irradiation group, the tumor did not grow up to day 6, and an initial rise and subsequent decrease in beta-ATP/Pi and PCr/Pi were observed. Maximum beta-ATP/Pi and PCr/Pi were observed on day 2 after irradiation. In a fractionation experiment, the greatest growth delay was observed in the two day interval group, in which maximum beta-ATP/Pi and PCr/Pi were demonstrated in 31P-MRS. Our results suggested that changes in the metabolites observed by 31P-MRS could be useful indicators for determining the fractionation schedule in radiation therapy.
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| Authors | O Murata, H Sakurai, N Mitsuhashi, M Hasegawa, M Yamakawa, H Kurosaki, K Hayakawa, H Niibe |
| Journal | Anticancer research (Anticancer Res) 1998 Nov-Dec Vol. 18 Issue 6A Pg. 4297-301 ISSN: 0250-7005 [Print] Greece |
| PMID | 9891481 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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