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Intracellular Leishmania amazonensis killing induced by the guanine nucleoside 8-bromoguanosine.

Abstract
In this study we investigated the effect of 8-Bromoguanosine, an immunostimulatory compound, on the cytotoxicity of macrophages against Leishmania amazonensis in an in vitro system. The results showed that macrophages treated with 8-Bromoguanosine before or after infection are capable to reduce parasite load, as monitored by the number of amastigotes per macrophage and the percentage of infected cells (i.e. phagocytic index). Since 8-Bromoguanosine was not directly toxic to the promastigotes, it was concluded that the ribonucleoside induced macrophage activation. Presumably, 8-Bromoguanosine primed macrophages by inducing interferon alpha and beta which ultimately led to L. amazonensis amastigote killing. The results suggest that guanine ribonucleosides may be useful to treat infections with intracellular pathogens.
AuthorsS Giorgio, S C Barão
JournalRevista do Instituto de Medicina Tropical de Sao Paulo (Rev Inst Med Trop Sao Paulo) 1998 Jul-Aug Vol. 40 Issue 4 Pg. 237-40 ISSN: 0036-4665 [Print] Brazil
PMID9876437 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Guanosine
  • 8-bromoguanosine
Topics
  • Adjuvants, Immunologic (pharmacology)
  • Animals
  • Cell Death (drug effects)
  • Guanosine (analogs & derivatives, pharmacology)
  • Leishmania (drug effects)
  • Macrophages (drug effects, physiology)
  • Mice

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