Abstract |
Cis-Octahydro-14H-benzo[g]quinolino[2,3-a]quinolidines 6 were obtained in 6 steps from L-phenylalanine. The key step utilizes a diastereoselective intramolecular EtAlCl2-catalyzed hetero-Diels-Alder reaction. Compounds 6a-f were tested in vitro against human medulloblastoma D283 Med and glioblastoma A-172 and T98G cell lines and showed improved cytotoxicity compared to the corresponding, less rigid pyrido[1,2-b] isoquinolines 1.
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Authors | A Monsees, S Laschat, M Hotfilder, P G Jones |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 8
Issue 20
Pg. 2881-4
(Oct 20 1998)
ISSN: 0960-894X [Print] England |
PMID | 9873641
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Quinolines
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Brain Neoplasms
(pathology)
- Cell Line
- Drug Screening Assays, Antitumor
- Humans
- Inhibitory Concentration 50
- Quinolines
(chemical synthesis, chemistry, pharmacology)
- Structure-Activity Relationship
- Tumor Cells, Cultured
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