Abstract | OBJECTIVE: METHODS: A cross-sectional diagnostic accuracy study was performed in a tertiary North American center, with the results of the dichotomous diagnostic test (the presence or absence of visible retinal emboli) being placed against the dichotomous outcome of the presence or absence of hemodynamically significant carotid artery stenosis (defined as > or = 60%, or < 60%, carotid artery stenosis on either side). RESULTS: Forty-eight (18.7%) of our 256 patients had hemodynamically significant carotid artery stenosis. The sensitivity and specificity of retinal emboli for the detection of hemodynamically significant carotid artery stenosis were 39% and 68%, respectively. The presence of a visible retinal embolus generated a likelihood ratio of 1.24 (95% confidence interval, 0.84-1.86). This value corresponds to a patient with a pretest probability of 50% having a posttest probability of 55.3%. The absence of a visible retinal embolus generated a likelihood ratio of 0.88 (95% confidence interval, 0.68-1.15). CONCLUSIONS:
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Authors | S Sharma, G C Brown, J L Pater, A F Cruess |
Journal | Archives of ophthalmology (Chicago, Ill. : 1960)
(Arch Ophthalmol)
Vol. 116
Issue 12
Pg. 1602-6
(Dec 1998)
ISSN: 0003-9950 [Print] United States |
PMID | 9869788
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carotid Stenosis
(diagnosis)
- Cross-Sectional Studies
- Female
- Hemodynamics
- Humans
- Likelihood Functions
- Male
- Middle Aged
- Pilot Projects
- Predictive Value of Tests
- Probability
- Reproducibility of Results
- Retinal Artery Occlusion
(diagnosis)
- Retinal Vessels
(pathology)
- Sensitivity and Specificity
- Thromboembolism
(diagnosis)
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