Abstract | BACKGROUND: METHODS: RESULTS:
Body weights and plasma cholinesterase activities of the high protein animals remained stable. Weights for the low protein and reduced intake animals fell by 5% and 15%, respectively (p < 0.05 for both vs baseline). Similarly, plasma cholinesterase activities for the low protein and reduced intake animals fell by 4% and 10%, respectively (p = 0.06 for low protein and < 0.05 for reduced intake vs baseline). Cocaine caused seizures in 67% of the high protein animals as compared to 93% and 100% of the low protein and reduced intake animals, respectively (p < 0.05 for high protein vs reduced intake). None of the high protein animals died as compared to 20% and 100% of the low protein and reduced intake animals, respectively (p < 0.05 for high protein vs reduced intake). CONCLUSION:
Protein and calorie malnutrition is associated with a reduction in plasma cholinesterase activity and enhanced cocaine toxicity in mice. Further study is needed to determine if dietary factors are partially responsible for variations in plasma cholinesterase activity and cocaine susceptibility in humans.
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Authors | R Cahill-Morasco, R S Hoffman, L R Goldfrank |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 36
Issue 7
Pg. 667-72
( 1998)
ISSN: 0731-3810 [Print] United States |
PMID | 9865234
(Publication Type: Journal Article)
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Chemical References |
- Dietary Proteins
- Cholinesterases
- Cocaine
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Topics |
- Animals
- Body Weight
(physiology)
- Cholinesterases
(blood)
- Cocaine
(toxicity)
- Diet
- Dietary Proteins
(administration & dosage)
- Female
- Mice
- Nutritional Status
- Protein-Energy Malnutrition
(chemically induced, physiopathology)
- Seizures
(chemically induced)
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