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[Antigenic activity of delta-antigen peptides corresponding to three genotypes of the delta hepatitis virus].

Abstract
Six synthetic peptides from immunodominant region 65-80 aa derived from the sequences of delta-antigen corresponding to 3 HDV genotypes were obtained. Their antigenic activities were assessed by indirect enzyme immunoassay with sera of patients with hepatitis D and of asymptomatic carriers of anti-delta antibodies. Differences in antigenic characteristics of full-size 65-80 and truncated 71-80 aa peptides corresponding to three HDV genotypes were revealed. The diagnostic significance of synthetic 65-80 aa fragments is shown.
AuthorsE V Dement'eva, I V Kruglov, V K Pimenov, Iu A Semiletov
JournalVoprosy virusologii (Vopr Virusol) 1998 Sep-Oct Vol. 43 Issue 5 Pg. 217-20 ISSN: 0507-4088 [Print] Russia (Federation)
Vernacular TitleAntigennaia aktivnost' peptidov del'ta-antigena, sootvetstvuiushchikh trem genotipam virusa gepatita del'ta.
PMID9864826 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibodies, Viral
  • Hepatitis Antigens
  • Hepatitis delta Antigens
  • Peptide Fragments
  • hepatitis delta virus large antigen
Topics
  • Amino Acid Sequence
  • Antibodies, Viral (blood)
  • Carrier State
  • Genotype
  • Hepatitis Antigens (chemistry, immunology)
  • Hepatitis D (immunology)
  • Hepatitis Delta Virus (genetics, immunology)
  • Hepatitis delta Antigens
  • Humans
  • Immunoenzyme Techniques
  • Molecular Sequence Data
  • Peptide Fragments (chemistry, immunology)

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