Abstract |
Six synthetic peptides from immunodominant region 65-80 aa derived from the sequences of delta-antigen corresponding to 3 HDV genotypes were obtained. Their antigenic activities were assessed by indirect enzyme immunoassay with sera of patients with hepatitis D and of asymptomatic carriers of anti-delta antibodies. Differences in antigenic characteristics of full-size 65-80 and truncated 71-80 aa peptides corresponding to three HDV genotypes were revealed. The diagnostic significance of synthetic 65-80 aa fragments is shown.
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Authors | E V Dement'eva, I V Kruglov, V K Pimenov, Iu A Semiletov |
Journal | Voprosy virusologii
(Vopr Virusol)
1998 Sep-Oct
Vol. 43
Issue 5
Pg. 217-20
ISSN: 0507-4088 [Print] Russia (Federation) |
Vernacular Title | Antigennaia aktivnost' peptidov del'ta-antigena, sootvetstvuiushchikh trem genotipam virusa gepatita del'ta. |
PMID | 9864826
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antibodies, Viral
- Hepatitis Antigens
- Hepatitis delta Antigens
- Peptide Fragments
- hepatitis delta virus large antigen
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Topics |
- Amino Acid Sequence
- Antibodies, Viral
(blood)
- Carrier State
- Genotype
- Hepatitis Antigens
(chemistry, immunology)
- Hepatitis D
(immunology)
- Hepatitis Delta Virus
(genetics, immunology)
- Hepatitis delta Antigens
- Humans
- Immunoenzyme Techniques
- Molecular Sequence Data
- Peptide Fragments
(chemistry, immunology)
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