The value of tissue polypeptide specific antigen TPS determination in serum of women with breast cancer comparison to mucin-like associated antigen MCA and CA 15-3 antigen.

The aim of the study was TPS diagnostic value determination in the serum of women with breast cancer as compared with MCA and CA 15-3. The relationship between the serum concentration of these antigens and patient age, clinical stage, histological grade, presence of metastases to lymph nodes and histological type of neoplasm was evaluated. Studies were conducted on the sera of 139 women before surgical procedure aged 28-81, treated in the Clinic of Oncology, at Karol Marcinkowski University of Medical Sciences in Poznań. The TPS concentration was determined using the "BEKI Diagnostics" immunoenzymatic method, MCA - by the "Roche" test and CA 15-3 concentration was determined by the "Abbott" immunofluorescent test. The study showed significantly higher levels of TPS, CA 15-3 and MCA in women with cancer, compared with values in healthy women and women with mastopathy. The highest median of concentration and frequency of occurrence was obtained for TPS. A correlation between enhancement of TPS and CA 15-3 concentration with clinical stage was observed. A similar connection was noted in women with metastases to the lymph nodes. Serum MCA concentration results did not demonstrate the above effects. The study suggests, that in estimating the clinical condition of women with breast cancer, the simultaneous determination of TPS with CA 15-3 seems to be a more useful prognostic factor than TPS or CA 15-3 with MCA.
AuthorsZ Kopczyński, A Thielemann
JournalEuropean journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 19 Issue 5 Pg. 503-7 ( 1998) ISSN: 0392-2936 [Print] ITALY
PMID9863926 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Mucin-1
  • Tissue Polypeptide Antigen
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Neoplasm (blood)
  • Biomarkers, Tumor (blood)
  • Breast Neoplasms (blood, diagnosis, pathology)
  • Carcinoma (blood, diagnosis, pathology, secondary)
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Middle Aged
  • Mucin-1 (blood)
  • Neoplasm Staging
  • Sensitivity and Specificity
  • Statistics, Nonparametric
  • Tissue Polypeptide Antigen (blood)

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