Oral granisetron prevents postoperative vomiting in children.

We have studied the efficacy of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, administered orally for the prevention of postoperative vomiting after tonsillectomy in children. In a randomized, double-blind, placebo-controlled study, 160 paediatric patients, ASA 1, aged 4-10 yr, received placebo or granisetron (20, 40 or 80 micrograms kg-1) (n = 40 each) orally, 1 h before surgery. A standard general anaesthetic technique was used throughout. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 40%, 48%, 85% and 90% of patients who had received placebo, or granisetron 20, 40 or 80 micrograms kg-1, respectively (P < 0.05; overall Fisher's exact probability test). There were no clinically important adverse events. We conclude that preoperative oral granisetron, in doses more than 40 micrograms kg-1, was effective for the prevention of postoperative vomiting in children.
AuthorsY Fujii, H Toyooka, H Tanaka
JournalBritish journal of anaesthesia (Br J Anaesth) Vol. 81 Issue 3 Pg. 390-2 (Sep 1998) ISSN: 0007-0912 [Print] ENGLAND
PMID9861127 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Retracted Publication)
Chemical References
  • Antiemetics
  • Serotonin Antagonists
  • Granisetron
  • Administration, Oral
  • Antiemetics (administration & dosage)
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Granisetron (administration & dosage)
  • Humans
  • Male
  • Postoperative Nausea and Vomiting (prevention & control)
  • Serotonin Antagonists (administration & dosage)
  • Tonsillectomy

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