Immunoblastic lymphadenopathy-like T cell lymphoma evolving into a massive plasma cell proliferation with biclonal paraproteinemia.

Abstract

We present a case of immunoblastic lymphadenopathy-like T cell lymphoma (IBL-T) who subsequently developed a massive proliferation of plasma cells. At diagnosis of IBL-T, the patient had polyclonal hypergammaglobulinemia and subsequently, while on chemotherapy, developed paraproteinemia with biclonal peaks and the IBL-T lesion was replaced with a massive proliferation of CD38-positive plasma cells. The evolution was not likely to be attributed to a new neoplastic proliferation of B cells. It appeared that two B cell clones possibly had a growth advantage among the polyclonal B cells due to a depletion of suppressor T cells or to a disturbance in the immune system.

• Authors: T Higuchi, J Tada, H Mori, H Niikura, M Omine, K Kishimoto, G Tate, T Mitsuya
• Journal: Acta haematologica (Acta Haematol) Vol. 100 Issue 3 Pg. 151-5 (Dec 1998) ISSN: 0001-5792 [Print] Switzerland
• PMID: 9858793 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD
• Antigens, Differentiation
• Membrane Glycoproteins
• ADP-ribosyl Cyclase
• CD38 protein, human
• NAD+ Nucleosidase
• ADP-ribosyl Cyclase 1

Topics

• ADP-ribosyl Cyclase
• ADP-ribosyl Cyclase 1
• Aged
• Antigens, CD
• Antigens, Differentiation
• Cell Division
• Female
• Flow Cytometry
• Fluorescent Antibody Technique, Indirect
• Humans
• Hypergammaglobulinemia (complications, immunology)
• Immunoblastic Lymphadenopathy (complications, immunology)
• Lymphoma, T-Cell (complications, immunology)
• Membrane Glycoproteins
• NAD+ Nucleosidase
• Paraproteinemias (complications, immunology)
• Plasma Cells (immunology, pathology)