Abstract |
Under continuous ECG and oxygen saturation (SpO2) monitoring, the following measurements were taken by Doppler echocardiography in 6 consecutive patients with tetralogy of Fallot (TF) before and after intravenous administration of disopyramide (2mg/kg): left ventricular shortening fraction (LVSF); peak velocities in the right ventricular outflow tract (RVOT); diastolic and systolic internal diameters of the right ventricular outflow tract (dRVOT, sRVOT); and systolic blood pressure. SpO2 increased (p<0.01) from 78 to 98 (89 +/- 7, mean +/- standard deviation)% to 86-99 (94 +/- 5)%. LVSF decreased (p<0.05) from 0.34-0.56 (0.42 +/- 0.08) to 0.22-0.54 (0.33 +/- 0.13). The systolic blood pressure fell slightly (p<0.05) from 68-92 (79 +/- 8) to 64-92 (71 +/- 11)mmHg. The sRVOT increased (p<0.05) from 2.1-4.8 (2.7 +/- 1.5)mm to 3.0-8.1 (4.9 +/- 2.4)mm, while RVOT peak velocity decreased (p<0.05) from 2.20-4.88 (3.70 +/- 0.97)m/sec to 2.05-4.07 (2.92 +/- 0.72)m/sec. Disopyramide alleviates hypoxia in patients of TF through its negative inotropic action on right ventricular outflow obstruction.
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Authors | H Tomita, S Fuse, K Hatakeyama, M Suzuki, S Chiba |
Journal | Japanese circulation journal
(Jpn Circ J)
Vol. 62
Issue 11
Pg. 807-10
(Nov 1998)
ISSN: 0047-1828 [Print] Japan |
PMID | 9856595
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Blood Flow Velocity
(drug effects)
- Blood Pressure
(drug effects)
- Child, Preschool
- Cyanosis
(drug therapy, etiology, physiopathology)
- Disopyramide
(therapeutic use)
- Echocardiography, Doppler
- Female
- Heart Ventricles
(diagnostic imaging)
- Humans
- Infant
- Male
- Tetralogy of Fallot
(complications, diagnostic imaging, physiopathology)
- Ventricular Function
(drug effects)
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