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[Pellagra (deficiency of vitamin B3 or of the amino acid tryptophan): a disease still extant in the Netherlands].

Abstract
Pellagra was diagnosed in a 48-year-old female patient with a bullous skin disease. The skin disease with purple/red sharply demarcated spots on hands and feet had worsened after sun exposure. She was a chronic alcoholic and for the last few months she had had diarrhoea. The treatment included vitamin B3, vitamin B complex and a high-quality protein diet. Within three days her skin disease improved. Pellagra is caused by a deficiency of nicotinamide or of its precursor tryptophan. It may occur in patients with dietary deficiency diseases (e.g. chronic alcoholics), carcinoid syndrome, HIV infections and drugs: fluorouracil, isoniazid, chloramphenicol and mercaptopurine. Pellagra leads to the triad: dermatitis, diarrhoea and dementia, eventually followed by death. The skin changes are characteristic and pathognomonic. Recognition of pellagra is important; the prognosis is good after treatment.
AuthorsS G Pasmans, A H Preesman, W A van Vloten
JournalNederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 142 Issue 33 Pg. 1880-2 (Aug 15 1998) ISSN: 0028-2162 [Print] Netherlands
Vernacular TitlePellagra (deficiëntie van vitamine B3 of van het aminozuur tryptofaan): een ziekte die nog steeds voorkomt in Nederland.
PMID9856171 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Amino Acids, Essential
  • Dietary Proteins
  • Niacinamide
  • Tryptophan
Topics
  • Alcoholism (complications)
  • Amino Acids, Essential (chemistry, deficiency)
  • Dietary Proteins (therapeutic use)
  • Female
  • Humans
  • Middle Aged
  • Niacinamide (therapeutic use)
  • Pellagra (complications, diagnosis, drug therapy)
  • Skin Diseases, Vesiculobullous (etiology)
  • Treatment Outcome
  • Tryptophan (chemistry, deficiency)

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