Abstract | BACKGROUND: METHODS: We performed a prospective, controlled study of the effects of naloxone on bladder function in rabbits with and without surgical transection of the spinal cord at the 10th thoracic vertebra. Acute and chronic stages of injury were defined according to bladder function. Naloxone was given intravenously at both stages, and intrathecally at the acute stage. Bladder activity was monitored by cystometry. Blood concentrations of methionine-enkephalin were measured by radioimmunoassay. RESULTS:
Spinal cord injuries were acute 1 or 2 days after surgery, and chronic after 1 or 2 weeks. Bladder capacity significantly decreased after 0.01 mg of intravenous naloxone in uninjured control rabbits, and after 0.03 mg of intravenous naloxone in rabbits with chronic-phase injuries. During the acute-injury phase, 0.3 mg of intravenous naloxone, or 0.02 mg of intrathecal naloxone, was necessary to evoke the micturition reflex. No significant changes in blood enkephalin levels were seen before or after spinal cord injury. CONCLUSION:
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Authors | H Kameoka, Y Shiraiwa, Y Fukaya, T Yokota, K Shishido, O Yamaguchi |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 5
Issue 6
Pg. 588-94
(Nov 1998)
ISSN: 0919-8172 [Print] Australia |
PMID | 9855129
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Disease Models, Animal
- Electromyography
- Enkephalins
(blood)
- Injections, Intravenous
- Injections, Spinal
- Male
- Naloxone
(administration & dosage, therapeutic use)
- Prospective Studies
- Rabbits
- Spinal Cord Injuries
(blood, physiopathology)
- Time Factors
- Urinary Bladder
(drug effects, physiology)
- Urodynamics
(drug effects)
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