Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.

Abstract

In the present study we investigated the chronopharmacological dependence of dose-dependent hypotensive and cardiochronotropic effects of the imidazoline-like drugs (clonidine, rilmenidine and moxonidine) in stroke-prone spontaneously hypertensive rats (SHR-SP), using radio-telemetric system (Data Sciences, USA). The 24-h blood pressure, heart rate and locomotor activity profiles showed peak values during the rats' active phase during the night period. The degree of hypotensive and bradycardic effects of all drugs were most evident at this time and occurred in the absence of a change in locomotor activity. These studies show that clonidine, rilmenidine and moxonidine decrease blood pressure and heart rate in a time-dependent manner in SHR-SP. It was demonstrated that the degree and duration of hypotensive action of imidazoline-like drugs vary with the time of drug administration.

• Authors: O S Medvedev, O R Kunduzova, A N Murashev, N A Medvedeva
• Journal: Journal of the autonomic nervous system (J Auton Nerv Syst) Vol. 72 Issue 2-3 Pg. 170-6 (Oct 15 1998) ISSN: 0165-1838 [Print] Netherlands
• PMID: 9851566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Imidazoles
• Oxazoles
• moxonidine
• Clonidine
• Rilmenidine

Topics

• Animals
• Antihypertensive Agents (pharmacology)
• Blood Pressure (drug effects)
• Cerebrovascular Disorders (genetics, physiopathology)
• Circadian Rhythm
• Clonidine (pharmacology)
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• Hypertension (genetics, physiopathology)
• Imidazoles (pharmacology)
• Male
• Motor Activity (drug effects)
• Oxazoles (pharmacology)
• Rats
• Rats, Inbred SHR
• Rilmenidine