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Posterior sub-Tenon's triamcinolone injections in the treatment of uveitis.

AbstractPURPOSE:
This is the first study reported in the United Kingdom to investigate the efficacy and safety of posterior, sub-Tenon's triamcinolone acetonide injections in the treatment of posterior and intermediate uveitis.
METHODS:
Twenty-eight posterior sub-Tenon's triamcinolone injections (40 mg) were given and the results analysed with a 6 month prospective follow-up in 13 cases.
RESULTS:
At 6 weeks follow-up, objective improvement in visual acuity occurred in 25 eyes (p < 0.05). Vitreous cellular activity was diminished in 21 eyes (p < 0.05). In most cases improvement was observed within 2 weeks of injection. No patient required repeat triamcinolone injection within 3 months and all patients previously treated with systemic immunosuppression were able to decrease or discontinue this treatment. Complications included transient elevation of intraocular pressure in 4 patients and persistent mild ptosis in 2 patients.
CONCLUSIONS:
We have demonstrated that posterior sub-Tenon's triamcinolone injection significantly decreases cystoid macular oedema, with a corresponding increase in visual acuity, in patients with posterior uveitis. Systemic immunosuppression may be reduced or discontinued with the avoidance of associated systemic side effects, and the technique has a high level of patient acceptability.
AuthorsV Tanner, J J Kanski, P A Frith
JournalEye (London, England) (Eye (Lond)) Vol. 12 ( Pt 4) Pg. 679-85 ( 1998) ISSN: 0950-222X [Print] England
PMID9850264 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • Triamcinolone
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Anti-Inflammatory Agents (administration & dosage)
  • Female
  • Follow-Up Studies
  • Glucocorticoids
  • Humans
  • Injections, Intralesional (methods)
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies
  • Treatment Outcome
  • Triamcinolone (administration & dosage)
  • Uveitis, Intermediate (drug therapy)
  • Uveitis, Posterior (drug therapy)
  • Visual Acuity

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