Abstract |
Sodium antimony gluconate (SAG) is the mainstay of treatment for visceral leishmaniasis (VL) or kala-azar. In view of the increasing incidence of refractoriness to SAG in India, we compared the levels of parasite-specific IgG and IgG subclasses in 20 longitudinally followed up kala-azar patients. In both SAG-responsive (n = 10) and unresponsive patients (n = 10), the levels of total IgG, IgG1, IgG2, IgG3 and IgG4 were increased, the rank order being IgG1 > IgG2 > IgG3 = IgG4. Following treatment, a significant decrease in total IgG and the four subclasses occurred in the SAG-responsive group, whereas in the SAG-unresponsive group these levels were unchanged or slightly increased. Therefore, monitoring of IgG1 and IgG2 levels in Indian kala-azar patients is a good serologic alternative to monitoring the disease status.
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Authors | M Chatterjee, K Basu, D Basu, D Bannerjee, N Pramanik, S K Guha, R P Goswami, S K Saha, C Mandal |
Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 114
Issue 3
Pg. 408-13
(Dec 1998)
ISSN: 0009-9104 [Print] England |
PMID | 9844051
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Protozoan
- Immunoglobulin G
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Topics |
- Animals
- Antibodies, Protozoan
(blood, classification)
- Follow-Up Studies
- Humans
- Immunoglobulin G
(blood, classification)
- India
- Leishmania donovani
(immunology)
- Leishmaniasis, Visceral
(immunology)
- Longitudinal Studies
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