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Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients.

Abstract
Sodium antimony gluconate (SAG) is the mainstay of treatment for visceral leishmaniasis (VL) or kala-azar. In view of the increasing incidence of refractoriness to SAG in India, we compared the levels of parasite-specific IgG and IgG subclasses in 20 longitudinally followed up kala-azar patients. In both SAG-responsive (n = 10) and unresponsive patients (n = 10), the levels of total IgG, IgG1, IgG2, IgG3 and IgG4 were increased, the rank order being IgG1 > IgG2 > IgG3 = IgG4. Following treatment, a significant decrease in total IgG and the four subclasses occurred in the SAG-responsive group, whereas in the SAG-unresponsive group these levels were unchanged or slightly increased. Therefore, monitoring of IgG1 and IgG2 levels in Indian kala-azar patients is a good serologic alternative to monitoring the disease status.
AuthorsM Chatterjee, K Basu, D Basu, D Bannerjee, N Pramanik, S K Guha, R P Goswami, S K Saha, C Mandal
JournalClinical and experimental immunology (Clin Exp Immunol) Vol. 114 Issue 3 Pg. 408-13 (Dec 1998) ISSN: 0009-9104 [Print] England
PMID9844051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Protozoan
  • Immunoglobulin G
Topics
  • Animals
  • Antibodies, Protozoan (blood, classification)
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G (blood, classification)
  • India
  • Leishmania donovani (immunology)
  • Leishmaniasis, Visceral (immunology)
  • Longitudinal Studies

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