Abstract | UNLABELLED: We examined the development of tolerance to the antiallodynic effect of chronic intrathecal (IT) administration of the adenosine analog R- phenylisopropyladenosine ( R-PIA) in a rat model of central pain after ischemic spinal cord injury. After 10 days of IT R-PIA treatment, the effect of IT morphine was also assessed to examine whether cross-tolerance between R-PIA and morphine was present. IT R-PIA completely alleviated allodynia-like behaviors to mechanical and cold stimuli in spinally injured rats. The anti-allodynic effect of R-PIA was maintained for 6-7 days with twice-daily administration and was reduced thereafter, particularly with respect to cold allodynia. IT morphine alleviated mechanical and cold allodynia in rats rendered tolerant to R-PIA to a degree comparable to that in R-PIA-naive (control) rats, which indicates that the anti-allodynic property of R-PIA is independent of the mechanisms by which morphine acts. The possibility of using agonists of adenosine receptors in treating refractory pain in patients with spinal cord injury is discussed. IMPLICATIONS:
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Authors | M von Heijne, J X Hao, W Yu, A Sollevi, X J Xu, Z Wiesenfeld-Hallin |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 87
Issue 6
Pg. 1367-71
(Dec 1998)
ISSN: 0003-2999 [Print] United States |
PMID | 9842828
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Purinergic P1 Receptor Agonists
- N-(1-methyl-2-phenylethyl)adenosine
- Morphine
- Adenosine
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Topics |
- Adenosine
(administration & dosage, analogs & derivatives)
- Analgesics
(administration & dosage)
- Analgesics, Opioid
(administration & dosage)
- Animals
- Chronic Disease
- Drug Tolerance
- Female
- Injections, Spinal
- Morphine
(administration & dosage)
- Pain
(drug therapy, etiology)
- Purinergic P1 Receptor Agonists
- Rats
- Rats, Sprague-Dawley
- Spinal Cord Injuries
(complications)
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