Abstract | BACKGROUND/AIMS: METHODOLOGY: RESULTS: Significant differences were recognized between the plasma AST, HA, TXB2, TNF-alpha, IL-1 alpha and energy charge levels, the degree of liver necrosis and survival rates of the two groups. Dose-dependent inhibition by SO of the production of TXB2, TNF-alpha and IL-1 alpha was observed. CONCLUSIONS: Regulation of TNF-alpha and IL-1 alpha by SO is possibly associated with the hepatoprotective effect of SO.
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Authors | Y Sugawara, Y Harihara, T Takayama, M Makuuchi |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
1998 Sep-Oct
Vol. 45
Issue 23
Pg. 1781-6
ISSN: 0172-6390 [Print] Greece |
PMID | 9840148
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adenine Nucleotides
- Interleukin-1
- Methacrylates
- Tumor Necrosis Factor-alpha
- Thromboxane A2
- 6-Ketoprostaglandin F1 alpha
- Hyaluronic Acid
- Aspartate Aminotransferases
- Dinoprostone
- ozagrel
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Topics |
- 6-Ketoprostaglandin F1 alpha
(blood)
- Adenine Nucleotides
(metabolism)
- Animals
- Aspartate Aminotransferases
(blood)
- Dinoprostone
(blood)
- Hyaluronic Acid
(blood)
- Interleukin-1
(metabolism)
- Liver
(blood supply, metabolism, pathology)
- Male
- Methacrylates
(pharmacology)
- Rats
- Rats, Inbred Strains
- Reperfusion Injury
(metabolism, pathology)
- Thromboxane A2
(antagonists & inhibitors)
- Tumor Necrosis Factor-alpha
(metabolism)
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