Enterovirus associated neurological disease in an HIV-1 infected man.

Abstract

We report a case of relapsing multifocal neurological disease associated with CNS echovirus 6 infection in an HIV-1-infected individual with no evidence of immunoglobulin deficiency. The illness was initially characterized by optic and cranial neuropathies and myelopathy; concurrent granulomatous hepatitis suggested disseminated viral infection. Treatment with combination nucleoside analogues led to partial remission, but a demyelinating polyneuropathy subsequently developed. There was improvement and sustained remission in the polyneuropathy following treatment with intravenous immunoglobulin. Neurotropic enterovirus infection may be involved in the pathogenesis of certain HIV-associated neurological syndromes.

• Authors: J R Dyer, R H Edis, M A French
• Journal: Journal of neurovirology (J Neurovirol) Vol. 4 Issue 5 Pg. 569-71 (Oct 1998) ISSN: 1355-0284 [Print] United States
• PMID: 9839655 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Adult
• Cranial Nerve Diseases (complications, virology)
• Demyelinating Diseases (complications, virology)
• Echovirus 6, Human (isolation & purification)
• Enterovirus Infections (complications, physiopathology, therapy, virology)
• HIV Infections (complications, virology)
• HIV-1
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Male
• Nervous System Diseases (complications, virology)