Familial Kaposi's sarcoma and Paget's disease of bone.

Abstract

Familial Kaposi's sarcoma and familial Paget's disease of bone have not previously been reported to occur in the one patient or the one family. We report on an 82-year-old female of Lebanese descent who was recently diagnosed with Kaposi's sarcoma and Paget's disease. Of the patient's eight siblings, seven had Paget's disease and two of these also had Kaposi's sarcoma. Histocompatibility leucocyte antigen (HLA) class I and II typing of the patient showed: A2, A3; B35, Bx; Bw6; Cw4; DR beta 1*1101 (an HLA-DR5 subtype), DR beta 3 and DQ beta 1*0301. Previous reports have described possible associations of familial Kaposi's sarcoma with HLA-DR5 and Paget's disease with DR2. DR beta 1*1104, DP beta 1*04 and DQw1. Genetic factors and possible viral aetiologies for each condition are reviewed.

• Authors: L R Hale, J W Kelly
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 39 Issue 4 Pg. 241-3 (Nov 1998) ISSN: 0004-8380 [Print] Australia
• PMID: 9838721 (Publication Type: Case Reports, Journal Article)

Chemical References

• HLA-DR5 Antigen

Topics

• Aged
• Aged, 80 and over
• Australia
• Female
• Genetic Predisposition to Disease
• HLA-DR5 Antigen (analysis)
• Histocompatibility Testing
• Humans
• Lebanon (ethnology)
• Osteitis Deformans (genetics, virology)
• Pedigree
• Sarcoma, Kaposi (genetics, virology)
• Skin Neoplasms (genetics, virology)
• Toes