Abstract | UNLABELLED: METHODS: A prospective study was performed on 41 patients (30 females, 11 males) with DTC (30 papillary, 11 follicular) who had undergone total thyroidectomy and received an average dose of 117 mCi (4329 MBq) of radioiodine for ablation of postsurgical residual thyroid tissue. All patients (n = 41) had 201Tl, 99mTc-tetrofosmin or 131I whole-body imaging after discontinuation of thyroid hormone replacement ( thyroxine-off group). Eight of 14 patients with distant metastases also were imaged when they were on thyroxine therapy both with 201Tl and 99mTc-tetrofosmin ( thyroxine on-and-off group). Radiologic studies (chest radiography, CT and MRI), serum thyroglobulin assays and histopathologic examinations were performed to clarify the presence of metastases with positive uptake on any of three radionuclide studies. RESULTS: In 26 of 41 patients all three scans were negative. These patients also clinically didn't show any evidence of metastases. Fourteen patients were considered to have distant metastases on the basis of clinical, radiologic and histopathologic findings. The sensitivities of 201Tl, 99mTc-tetrofosmin and 131I in diagnosing distant metastases were comparable (0.85, 0.85 and 0.78, respectively). Iodine-131 was much more sensitive than 201Tl and 99mTc-tetrofosmin for demonstrating residual thyroid tissue after surgery (1.00, 0.33 and 0.33, respectively). The only false-positive case involved radioiodine uptake in a tuberculoma. Thyroxine-on images of 8 patients with distant metastases showed no difference from their thyroxine-off images regarding the site, number and uptake of metastases. CONCLUSION:
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Authors | S Unal, Y Menda, I Adalet, H Boztepe, N Ozbey, F Alagöl, S Cantez |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 39
Issue 11
Pg. 1897-902
(Nov 1998)
ISSN: 0161-5505 [Print] United States |
PMID | 9829579
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Iodine Radioisotopes
- Organophosphorus Compounds
- Organotechnetium Compounds
- Radiopharmaceuticals
- Thallium Radioisotopes
- technetium tc-99m tetrofosmin
- Thyroxine
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Topics |
- Adenocarcinoma, Follicular
(diagnostic imaging, secondary)
- Adult
- Carcinoma, Papillary
(diagnostic imaging, secondary)
- Case-Control Studies
- Female
- Humans
- Iodine Radioisotopes
- Male
- Organophosphorus Compounds
- Organotechnetium Compounds
- Prospective Studies
- Radionuclide Imaging
- Radiopharmaceuticals
- Sensitivity and Specificity
- Thallium Radioisotopes
- Thyroid Neoplasms
(pathology)
- Thyroxine
(therapeutic use)
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