Abstract | INTRODUCTION: PATIENTS AND METHODS: From 1983 through 1995, in 889 patients with NSCLC, who underwent pulmonary resection, 123C3 reactivity was tested. NCAM was correlated with tumor histology, p-TNM stage, and 5-year survival. Large cell NE carcinomas were excluded. Monoclonal antibody-1 (MOC-1) was also tested on most specimens. RESULTS: Reactivity of 123C3 does not correlate with tumor histology, p-TNM stage, or 5-year survival. In addition, MOC-1 reactivity was not significantly related to prognosis. CONCLUSIONS: Positive reactivity with 123C3, indicating NE differentiation, does not have predictive value in NSCLC. Also, tumor histology or stage did not correlate with 123C3 reactivity. Reactivity of MOC-1 did not contribute to prediction of prognosis. Whether there is more chemosensitivity in NSCLC-NE than in NSCLC without NE differentiation remains an important question that is not addressed by our present study.
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Authors | R Hage, H R Elbers, A Brutel de la Rivière, J M van den Bosch |
Journal | Chest
(Chest)
Vol. 114
Issue 5
Pg. 1316-20
(Nov 1998)
ISSN: 0012-3692 [Print] United States |
PMID | 9824008
(Publication Type: Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Neural Cell Adhesion Molecules
|
Topics |
- Adenocarcinoma
(metabolism, mortality)
- Antigens, Neoplasm
(metabolism)
- Carcinoma
(metabolism, mortality)
- Carcinoma, Non-Small-Cell Lung
(metabolism, mortality, pathology, surgery)
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(metabolism, mortality, pathology, surgery)
- Male
- Neural Cell Adhesion Molecules
(metabolism)
- Prognosis
- Survival Rate
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