Abstract | BACKGROUND: OBSERVATIONS: We present two patients with chronic inflammatory, demyelinating polyneuropathy, who after the first course of IVIg developed a folliculocentric interface/ lichenoid eruption that cleared without therapy or with topical steroids. The eruption did not recur with subsequent IVIg infusions in either patient. CONCLUSIONS: The multiple diverse effects of IVIg on the immune system, and the re-regulation of the anti-idiotype network with repeat IVIg infusions, may explain why this eruption occurred with the initial infusion of IVIg and not with repeated infusions.
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Authors | K J Smith, A L Dutka, H G Skelton |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
Vol. 3
Issue 2
Pg. 96-101
(Oct 1998)
ISSN: 1203-4754 [Print] United States |
PMID | 9822784
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Anti-Idiotypic
- Immunoglobulins, Intravenous
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Topics |
- Aged
- Antibodies, Anti-Idiotypic
(immunology)
- Demyelinating Diseases
(immunology, therapy)
- Drug Eruptions
(immunology, pathology)
- Female
- Humans
- Immunoglobulins, Intravenous
(adverse effects, immunology)
- Immunohistochemistry
- Lichenoid Eruptions
(chemically induced, pathology)
- Male
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