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Henoch Schönlein purpura and amebiasis.

Abstract
The pathogenesis of Henoch Schönlein purpura (HSP) is unknown but is believed to result from an immune complex reaction to various antigenic stimuli, such as infectious agents. However, its association with Entamoeba histolytica has not been reported before. We present an 11-year-old boy with HSP, confirmed by the demonstration of leukocytoclastic vasculitis from skin and diffuse endocapillary proliferative glomerulonephritis, together with immunoglobulin A and complement component C3 deposition from renal biopsies. Cysts and trophozoites of Entamoeba histolytica were detected from the stool of the patient at the same time and disappeared after the treatment with metranidasole. The temporal association of these two disorders is either coincidental or due to a causal relationship between them.
AuthorsG Demircin, A Oner, O Erdoğan, M Bülbül, L Memiş
JournalActa paediatrica Japonica : Overseas edition (Acta Paediatr Jpn) Vol. 40 Issue 5 Pg. 489-91 (Oct 1998) ISSN: 0374-5600 [Print] Australia
PMID9821714 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Infective Agents
  • Metronidazole
Topics
  • Animals
  • Anti-Infective Agents (therapeutic use)
  • Child
  • Entamoeba histolytica (isolation & purification)
  • Entamoebiasis (complications, diagnosis, drug therapy)
  • Feces (parasitology)
  • Humans
  • IgA Vasculitis (drug therapy, etiology, parasitology)
  • Male
  • Metronidazole (therapeutic use)

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