Abstract | BACKGROUND: Although experimental induction of panic by infusion of 0.5 mol/L sodium lactate in persons with panic disorder was described three decades ago, the mechanism underlying this observation remains unclear. Here we asked if the rapid administration of the large sodium load contained in the 0.5-mol/L sodium lactate infusion might be involved in panic induction. METHODS: RESULTS: CONCLUSIONS:
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Authors | E R Peskind, C F Jensen, M Pascualy, D Tsuang, D Cowley, D C Martin, C W Wilkinson, M A Raskind |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 44
Issue 10
Pg. 1007-16
(Nov 15 1998)
ISSN: 0006-3223 [Print] United States |
PMID | 9821565
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Saline Solution, Hypertonic
- Arginine Vasopressin
- Lactic Acid
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Acidosis
(blood, chemically induced)
- Adrenocorticotropic Hormone
(blood)
- Adult
- Alkalosis
(blood, chemically induced)
- Arginine Vasopressin
(blood)
- Double-Blind Method
- Female
- Humans
- Hydrocortisone
(blood)
- Hypernatremia
(blood, chemically induced)
- Lactic Acid
(pharmacology)
- Male
- Panic
(drug effects)
- Panic Disorder
(metabolism, psychology)
- Saline Solution, Hypertonic
(pharmacology)
- Water-Electrolyte Balance
(drug effects)
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