Abstract | PURPOSE: METHODS: We describe a 49-year-old female patient with the mild form of the disease (MPS VI-B) who developed bilateral increasing corneal opacification and increased intraocular pressure after cervical-fusion surgery. After treatment of the increased intraocular pressure, she underwent a penetrating keratoplasty of her right eye. RESULTS: The histopathologic and ultrastructural features of the corneal button were the accumulation of membrane-bound vacuoles containing fibrillogranular and lamellated material in keratocytes and endothelial cells and thinning of Descemet's membrane with excrescences. CONCLUSION: Our review of the literature reveals only two prior histologic studies of corneas affected by MPS VI B.
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Authors | N M Laver, M H Friedlander, I W McLean |
Journal | Cornea
(Cornea)
Vol. 17
Issue 6
Pg. 664-8
(Nov 1998)
ISSN: 0277-3740 [Print] United States |
PMID | 9820948
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Cervical Vertebrae
(surgery)
- Cornea
(surgery, ultrastructure)
- Corneal Opacity
(etiology, pathology, surgery)
- Female
- Follow-Up Studies
- Humans
- Intraocular Pressure
- Keratoplasty, Penetrating
- Middle Aged
- Mucopolysaccharidosis VI
(complications, pathology, surgery)
- Ocular Hypertension
(etiology, pathology)
- Spinal Fusion
(adverse effects)
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