Abstract | BACKGROUND: METHODS: One hundred consecutive critically ill patients were prospectively studied for the development of infectious complications, organ dysfunction, and SIRS. Urine was collected daily for measurement of IFABP. RESULTS: A total of 58 males and 42 females (mean age, 56 years; range,16-85 years) were studied. Of these 100 patients, 40 patients developed complications and 5 patients developed SIRS. IFABP was significantly elevated in all patients with SIRS, and IFABP levels peaked an average of 1.4 days (range, 0-7 days) before the diagnosis of SIRS. CONCLUSION: Elevated concentrations of urine IFABP correlated with the clinical development of SIRS. Studies to assess the utility of IFABP as a predictor of organ dysfunction and SIRS in the critically ill are warranted.
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Authors | J M Lieberman, W H Marks, S Cohn, R Jaicks, L Woode, J Sacchettini, B Fischer, B Moller, G Burns |
Journal | The Journal of trauma
(J Trauma)
Vol. 45
Issue 5
Pg. 900-6
(Nov 1998)
ISSN: 0022-5282 [Print] United States |
PMID | 9820701
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Carrier Proteins
- FABP7 protein, human
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Myelin P2 Protein
- Neoplasm Proteins
- Tumor Suppressor Proteins
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(urine)
- Carrier Proteins
(urine)
- Critical Care
- Fatty Acid-Binding Protein 7
- Fatty Acid-Binding Proteins
- Female
- Follow-Up Studies
- Humans
- Infections
(urine)
- Intestinal Mucosa
(blood supply)
- Ischemia
(urine)
- Male
- Middle Aged
- Multiple Organ Failure
(urine)
- Myelin P2 Protein
(urine)
- Neoplasm Proteins
- Predictive Value of Tests
- Reproducibility of Results
- Systemic Inflammatory Response Syndrome
(urine)
- Time Factors
- Tumor Suppressor Proteins
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