Abstract |
Fluorine-18-fluorodeoxyglucose (F-18 FDG) PET was used to evaluate early-stage larynx cancer before and after radiotherapy. Less radical salvage surgery might be possible after timely diagnosis of recurrent or persistent tumor after radiotherapy. Eight patients with early-stage laryngeal cancer (two carcinoma in situ; six stage T1: tumor limited to vocal cords with normal mobility) underwent irradiation for potential cure. Five patients had pre- and postradiotherapy F-18 FDG PET, and three had postradiotherapy F-18 FDG PET only. All patients underwent a CT scan of the neck at the time of the F-18 FDG PET scan. One patient had a positive result of postradiotherapy F-18 FDG PET but a negative result of a CT of the neck, and biopsy revealed recurrent squamous carcinoma. Seven patients who had negative results of postradiotherapy F-18 FDG PET were free of disease at the 15-month median follow-up evaluation. (Three of them had no cancer on biopsy of the larynx, and four others were followed with periodic endoscopic examinations that revealed complete disappearance of the tumor.) F-18 FDG PET scan may be useful for earlier diagnosis of recurrent or persistent laryngeal cancer after radiotherapy and is preferable to repeated biopsies, which would traumatize radiation-damaged tissues. A prompt early diagnosis of failure of radiotherapy will lead to less radical salvage surgery.
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Authors | H J Kim, J Boyd, F Dunphy, V Lowe |
Journal | Clinical nuclear medicine
(Clin Nucl Med)
Vol. 23
Issue 11
Pg. 750-2
(Nov 1998)
ISSN: 0363-9762 [Print] United States |
PMID | 9814562
(Publication Type: Journal Article)
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Chemical References |
- Fluorine Radioisotopes
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Carcinoma in Situ
(diagnostic imaging, radiotherapy)
- Carcinoma, Squamous Cell
(diagnostic imaging)
- Fluorine Radioisotopes
- Fluorodeoxyglucose F18
- Humans
- Laryngeal Neoplasms
(diagnostic imaging, radiotherapy)
- Middle Aged
- Neoplasm Recurrence, Local
(diagnostic imaging)
- Neoplasm Staging
- Radiopharmaceuticals
- Time Factors
- Tomography, Emission-Computed
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