Abstract | OBJECTIVE: METHODS: Patients with both enhancing and nonenhancing tumors were treated with up to six cycles of standard PCV, and response was evaluated by conventional criteria based on computed tomography or magnetic resonance imaging. RESULTS: Sixteen of 26 patients (62%) responded to PCV: 3 (12%) experienced complete response, 13 (50%) experienced partial response, 8 (31%) had stable disease, and 2 (8%) had progressive disease. All symptomatic patients who responded and three with stable disease improved in seizure frequency, lateralizing signs, and symptoms of intracranial hypertension. The response rate for patients with enhancing lesions revealed by computed tomography or magnetic resonance imaging (74%) was significantly higher than that of patients with nonenhancing lesions (29%) (P < 0.05). Both oligodendrogliomas and oligoastrocytomas responded to PCV, with complete responses occurring in association with pure tumors only. The median time to tumor progression of all 26 patients was 24 months and was significantly longer for those with oligodendrogliomas compared with those with oligoastrocytomas (32 versus 12 mo) (P < 0.001). Chemotherapy was well tolerated, with mild hematological toxicity and rare skin rashes being the most frequent sequelae. CONCLUSION:
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Authors | R Soffietti, R Rudà, G B Bradac, D Schiffer |
Journal | Neurosurgery
(Neurosurgery)
Vol. 43
Issue 5
Pg. 1066-73
(Nov 1998)
ISSN: 0148-396X [Print] United States |
PMID | 9802850
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Taxoids
- Vinblastine
- Paclitaxel
- Cisplatin
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Brain Neoplasms
(drug therapy, radiotherapy, surgery)
- Cisplatin
(administration & dosage, adverse effects)
- Combined Modality Therapy
- Disease Progression
- Female
- Follow-Up Studies
- Glioma
(drug therapy, radiotherapy, surgery)
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Oligodendroglioma
(drug therapy, radiotherapy, surgery)
- Paclitaxel
(administration & dosage, adverse effects)
- Radiotherapy, Adjuvant
- Taxoids
- Tomography, X-Ray Computed
- Treatment Outcome
- Vinblastine
(administration & dosage, adverse effects, analogs & derivatives)
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