Abstract | OBJECTIVES: METHODS: The GnRH test was performed in 121 infertile men with varicocele before surgical correction and 4 to 6, 9 to 12, and 16 to 18 months after. Levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were evaluated immediately before the test and 45 minutes after intravenous injection of 100 jig Relisorm L (a synthetic GnRH analogue). Eighteen fertile men with normal semen parameters served as control patients for defining the preoperative hormone levels. A more than twofold increase in FSH and a more than fivefold increase in LH was considered a positive result. Findings were correlated with semen parameters and rate of pregnancy in the patients' wives at 18 months postoperatively. RESULTS: Of the 121 patients, 89 (73.5%) had a positive GnRH test result, and 32 had a negative result. Semen parameters were improved postoperatively in 72 of the GnRH-positive patients (80.9%) and in only 6 of the GnRH-negative patients (1 8.7%). Corresponding pregnancy rates at 18 months in the two subgroups were 60 (67.4%) and 3 (9.3%), respectively. CONCLUSIONS: A positive preoperative GnRH test is a good predictor of improvement in semen parameters and pregnancy after varicocele surgery. We suggest that the GnRH test can serve as an additional indicator for varicocelectomy.
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Authors | E Segenreich, S Israilov, J Shmuele, E Niv, J Baniel, P Livne |
Journal | Urology
(Urology)
Vol. 52
Issue 5
Pg. 853-7
(Nov 1998)
ISSN: 0090-4295 [Print] United States |
PMID | 9801113
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Gonadotropin-Releasing Hormone
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adult
- Female
- Follicle Stimulating Hormone
(blood)
- Gonadotropin-Releasing Hormone
(blood)
- Humans
- Infertility, Male
(blood, etiology)
- Luteinizing Hormone
(blood)
- Male
- Middle Aged
- Postoperative Care
- Pregnancy
(statistics & numerical data)
- Preoperative Care
- Sperm Count
- Varicocele
(blood, complications, surgery)
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