Nasal high frequency ventilation in neonates with moderate respiratory insufficiency.

Abstract

AIM:

To investigate the efficacy of nasal high frequency ventilation (nHFV) in newborn infants with moderate respiratory insufficiency.

METHOD:

Twenty one preterm and term neonates were treated with nHFV for respiratory insufficiency. Criteria for starting nHFV were: deterioration on nasal CPAP expressed by a median pH of 7.24 and pCO2 of 8.3 kPa, or increasing FIO2. nHFV was delivered using the Infant Star ventilator. Ventilator setting amplitude was 35 cm H2O; mean airway pressure 7 cm H2O; and frequency 10 Hz.

RESULTS:

pCO2 decreased significantly from 8.3 kPa to 7.2 kPa after nHFV was started. In five patients nHFV was discontinued after a median period of 6 1/2 hours due to CO2 retention and high oxygen need, and endotracheal mechanical ventilation was started.

CONCLUSIONS:

nHFV can reduce pCO2 in neonates with moderate respiratory insufficiency and, therefore, could be used to decrease the need for endotracheal mechanical ventilation.

• Authors: M van der Hoeven, E Brouwer, C E Blanco
• Journal: Archives of disease in childhood. Fetal and neonatal edition (Arch Dis Child Fetal Neonatal Ed) Vol. 79 Issue 1 Pg. F61-3 (Jul 1998) ISSN: 1359-2998 [Print] England
• PMID: 9797628 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Carbon Dioxide

Topics

• Carbon Dioxide (blood)
• High-Frequency Ventilation
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (blood, therapy)
• Respiratory Distress Syndrome, Newborn (blood, therapy)
• Treatment Outcome