Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion.

Abstract

OBJECTIVE:

To determine the presence of the major outer-membrane protein of Chlamydia trachomatis in fallopian tube tissue specimens of infertile women with chronic salpingitis and/or salpingitis isthmica nodosa with tubal occlusion.

DESIGN:

Prospective controlled study.

SETTING:

Department of Obstetrics and Gynecology, University of Bochum, Herne, Germany.

PATIENT(S):

Fifty-six consecutive infertile women with histologically documented chronic salpingitis and/or salpingitis isthmica nodosa and bilateral tubal occlusions were evaluated. They were compared with 28 fertile women.

INTERVENTION(S):

Fallopian tube tissue specimens were taken during reconstructive infertility surgery, including cesarean section and tubal ligation.

MAIN OUTCOME MEASURE(S):

Detection of the major outer-membrane protein of C. trachomatis in fallopian tube tissue specimens by a direct fluorescent antibody test.

RESULT(S):

The major outer-membrane protein of C. trachomatis was found in fallopian tube tissue specimens in 11 of 56 infertile patients (20%) with chronic salpingitis and/or salpingitis isthmica nodosa. The median titer of IgG serum antibodies to Chlamydia was significantly higher in women with the major outer-membrane protein of C. trachomatis than in patients without this antigen. In comparison, the major outer-membrane protein of C. trachomatis was not found in any of the fallopian tube tissue specimens of the control group.

CONCLUSION(S):

The presence of the major outer-membrane protein of C. trachomatis is associated with chronic salpingitis and/or salpingitis isthmica nodosa with tubal occlusion.

• Authors: S Dieterle, C Rummel, L W Bader, H Petersen, T Fenner
• Journal: Fertility and sterility (Fertil Steril) Vol. 70 Issue 4 Pg. 774-6 (Oct 1998) ISSN: 0015-0282 [Print] United States
• PMID: 9797114 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Bacterial Outer Membrane Proteins

Topics

• Adult
• Bacterial Outer Membrane Proteins (analysis)
• Chlamydia trachomatis
• Chronic Disease
• Fallopian Tube Diseases (microbiology)
• Female
• Humans
• Infertility, Female (microbiology)
• Prospective Studies
• Salpingitis (microbiology)